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Origin
Pentosan polysulphate sodium is a semi-synthetic polysaccharide made from beech wood. It is a linear macromolecule assigned to polyelctrolytes as a sulphated polyanion.
Areas of Application
Pentosan polysulphate sodium has been successfully marketed for over 50 years as an ointment and gel for the treatment of superficial venous inflammations or haematomata from bruises, torn muscle fibres or pulling/tearing of ligaments. As a tablet and injection solution, pentosan polysulphate sodium was traditionally used to support the treatment of arteriosclerotic vascular diseases and Claudikatio Intermittens.
An important area of application is the use of pentosan polysulphate sodium for interstitial cystitis. Interstitial cystitis is a serious chronic inflammation of the urinary bladder without evidence of a bacterial infection.
As a veterinary medicinal product, pentosan polysulphate sodium is used worldwide for the treatment of non-infectious diseases of the locomotor system (i.e. osteoarthritis), for the treatment of lameness and the soothing of pain symptoms.
Specifications:
Items | Specifications | Results |
Appearance | White or off white powder | Off white powder |
Identification | 1H- NMR spectrum | Complied |
Average MW | 4000-7000 Daltons | 5530 |
Content of LMW component | NMT 12.0 % | 8.6% |
Ph | 4.5 to 6.5 | 5.5 |
Sulphur content | 13.0 to 20.0 wt% | 15.3% |
D-Glucuronic acid content | 7.0 to 12.0 wt% | 9.3% |
Heavy metals | NMT 30 ppm | Passed |
Solubility | Soluble in water, sparingly soluble in 0.1 N NaOH solution and practivally insoluble in methanol | |
Results | The product conforms to the above specifications | |
Origin
Pentosan polysulphate sodium is a semi-synthetic polysaccharide made from beech wood. It is a linear macromolecule assigned to polyelctrolytes as a sulphated polyanion.
Areas of Application
Pentosan polysulphate sodium has been successfully marketed for over 50 years as an ointment and gel for the treatment of superficial venous inflammations or haematomata from bruises, torn muscle fibres or pulling/tearing of ligaments. As a tablet and injection solution, pentosan polysulphate sodium was traditionally used to support the treatment of arteriosclerotic vascular diseases and Claudikatio Intermittens.
An important area of application is the use of pentosan polysulphate sodium for interstitial cystitis. Interstitial cystitis is a serious chronic inflammation of the urinary bladder without evidence of a bacterial infection.
As a veterinary medicinal product, pentosan polysulphate sodium is used worldwide for the treatment of non-infectious diseases of the locomotor system (i.e. osteoarthritis), for the treatment of lameness and the soothing of pain symptoms.
Specifications:
Items | Specifications | Results |
Appearance | White or off white powder | Off white powder |
Identification | 1H- NMR spectrum | Complied |
Average MW | 4000-7000 Daltons | 5530 |
Content of LMW component | NMT 12.0 % | 8.6% |
Ph | 4.5 to 6.5 | 5.5 |
Sulphur content | 13.0 to 20.0 wt% | 15.3% |
D-Glucuronic acid content | 7.0 to 12.0 wt% | 9.3% |
Heavy metals | NMT 30 ppm | Passed |
Solubility | Soluble in water, sparingly soluble in 0.1 N NaOH solution and practivally insoluble in methanol | |
Results | The product conforms to the above specifications | |